Brain Supplements

Sulbutiamine: An Amazing Vitamin B1 Derivative

Sulbutiamine vitamin fruits

Sulbutiamine is an artificial version of vitamin B1 (thiamine). It is made up of 2 thiamine molecules connected by a sulfur group. However, it is unlike thiamine which dissolves in water because it dissolves in fats. The chemical has the ability to increase levels of thiamine in the brain. Sulbutiamine also goes by the names Youvitan, Enerion, Arcalion, Bisibuthiamine

Sulbutiamine was created by the Japanese for the purpose of combating chronic B1 deficiency. Vitamin B1 deficiency can significantly affect your cognitive function. You may have poor memory, reduced alertness, low attention span, lack of energy, and even bad mood. Some people with a vitamin B1 deficiency can develop depression, which is only made worse by the lack of energy.

Supplementing with sulbutiamine has a positive effect on mood, cognition, and energy. The supplement can also benefit healthy individuals who don’t suffer from a vitamin B1 deficiency.

A Little History on Sulbutiamine

In the 1950s, efforts to develop synthetic versions of thiamine with better bioavailability became enhanced (particularly in Japan). During this time, allicin, a compound found in garlic was discovered. Allicin became a model for efforts to develop other thiamine disulfides. As a result, sulbutiamine, benfothiamine, and fursultiamine were created. These three compounds are hydrophobic and easily move from the intestines to the bloodstream where they are converted into thiamine by glutathione or cysteine.

How Sulbutiamine Works

Since sulbutiamine is a synthetic version of thiamine, it offers the positive effects of the vitamin. The major reason people supplement with sulbutiamine is because of its ability to quickly cross the blood-brain barrier (even quicker than thiamine), giving faster results. Since sulbutiamine dissolves in fats, it circulates swiftly throughout the brain and the body, giving the user its positive benefits.

Sulbutiamine easily crosses the blood-brain barrier and enters the central nervous system. Once it does this, it increases the levels of thiamine and thiamine esters in the brain. Sulbutiamine can selectively work on the areas of the brain that control conditions like anxiety.

Sulbutiamine also interacts with the transmission systems and receptor sites for specific neurotransmitters that control behavior – namely dopamine, acetylcholine, and glutamate. All three neurotransmitters play an important role in the most basic cognitive processes that dictate the way we think, feel, and what we focus on.

For instance, dopamine is connected to mood and is discharged in response to the brain’s reward system. Glutamate and acetylcholine play a role in creating and retrieving memories. Additionally, acetylcholine is involved in executive function and the capacity to block out or concentrate on certain stimuli.


Since a vitamin B1 deficiency affects cognitive ability, clinical studies have been conducted on thiamine and its derivatives – like sulbutiamine – to determine their benefits for cognitive function.

In a clinical study conducted on individuals with early stage Alzheimer’s Disease, the researchers concluded that sulbutiamine can modify the effect of anticholinesterasic drugs in early stage and moderate Alzheimer’s disease.

Sulbutiamine has also been studied as a possible remedy for chronic fatigue syndrome.

The Benefits of Sulbutiamine

Improves Memory

Perhaps the most popular of sulbutiamine’s effects is the ability to enhance memory – just like other powerful memory enhancers. People who take the supplement regularly have reported a significant improvement in their ability to absorb and retain information. They report an improvement in both short-term and long-term memory.

While the exact process of how sulbutiamine affects memory is still being studied, scientists suggest that the substance indirectly improves memory by enhancing the function of the brain’s neurons, especially their communication abilities and their basic transmission. This is a result of the effect sulbutiamine has on the substances (acetylcholine, glutamate, and dopamine) that regulate these crucial brain activities.

Enhances Mood and Lowers Anxiety

Sulbutiamine can have a positive effect on general mood, at least anecdotally. It can be very helpful in lowering anxiety because of its ability to increase the amount of dopamine in the brain. It can help increase focus and concentration on tasks and the general surroundings, improving mood in the process.

Because of its ability to improve concentration and focus, it can considerably lower general nervousness and anxiety, especially in social situations. People who experience a lot of fear and misapprehension in social situations say they handle such situations better after taking sulbutiamine.

The supplement reduces anxiety by working on the chemical imbalances that bring it on. It may also be ideal for individuals who feel that their anxiety is affecting their focus and productivity.

While sulbutiamine does not exhibit the classic characteristics of an anxiolytic compound, it has a good effect on both mood and attention switching. It may also be helpful to people who suffer from performance anxiety. It can boost confidence and help a shy person to block negative thoughts. It has also been shown to improve verbal fluidity, helping people with social anxiety to talk confidently in group settings.

Boosts Energy Levels and Alertness

Sulbutiamine can increase both physical and mental energy. The energy it gives is not followed by a crash as is the case with other stimulants like caffeine. It can reduce feelings of weakness and is used by some athletes as a stimulant. One of the major roles of Vitamin B1 is to convert carbohydrates into energy. It also plays an important role in energy production. These are some of the roles that sulbutiamine mimics.


Sulbutiamine comes in both pill and powder form. Buying the powder is a lot cheaper as there are manufacturing costs attached to pills. But users say the powder has a foul smell that is difficult to mask and can make you gag when ingesting it.

After you buy sulbutiamine, either in pill or powder form, you need to determine the right dosage for you. The dosage depends on various factors like your sex, age, weight, and sensitivities.

The recommended sulbutiamine dosage is 400 mg to 100 mg every 24 hours.

These dosage recommendations are general, so your dosage may be different. You may also want to speak to a medic before you start taking a new supplement. Use a safe dosage for your needs.

Sulbutiamine powder is fat-soluble and cannot mix with juices or water. When taking it, mix it with a glass of fish oil, milk, or food. To ensure the chemical is quickly absorbed in your digestive system, take it with a lipid.


As with all supplements, sulbutiamine will become less effective if you take it regularly for a long period of time. In order to prevent tolerance, you must cycle it to ensure the receptors it affects don’t get used to it.

One way to go about this is to stack the nootropic with other nootropics like piracetam and Alpha GPC and have regular cycles. For instance, you can take the stack for one whole week then stop taking it for a whole week. Stacking sulbutiamine with synergistic compounds may give you a better overall experience as you get the benefits from each nootropic.

Side Effects

Sulbutiamine is generally safe for human consumption and doesn’t have harmful side effects. Its most common side effect is increasing irritability and anxiety. A few users have also said they experience nausea after taking the supplement. But it is worth noting that these specific side effects appear when individuals exceed the recommended dosages.

Where Can You Buy Sulbutiamine?

Depending on your budget, you can get sulbutiamine in either pill or powder form. If you prefer pills, you can buy them on Amazon. Most bottles contain 50-100 capsules and sell for less than $25.

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